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Data on the prevalence of never, former, and current smokers in each sex and age subgroup were obtained from the 2003 survey conducted by the Italian National Institute of Statistics (ISTAT) 19 and are shown in Supplementary file Table 1

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Epigenetics can be thought of as additional information added on top of our DNA in response to our environment

GWAS of serum concentrations without adjusting for smoking habits Without adjusting for smoking habits, we identified no genome-wide significant loci in our GWAS of CLZ serum concentration (Fig